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Comparing the signal enhancement of a gadolinium based and an iron ...
Gadolinium based contrast agents (GBCAs) are used for generating positive contrast in millions of MRI examinations because of their unique magnetic properties [2]. An important characteristic of CAs in MRI is that their effect depends on the used field strength [3].
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Gadolinium - SpringerLink
Most stable technogenic radionuclide 160 Gd (half-life > 1.3 × 10 21 years). The most common compounds: Gd 2 O 3, GdF 3, and Gd(OH) 3.
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[Pharmacokinetics of gadolinium-based contrast agents]
Results: Gadolinium-based contrast agents are distributed rapidly within the body and are eliminated by the kidneys. A fast initial elimination (half-life approximately 2 h) is followed by a slow elimination phase (half-life approximately 6 days), reflecting slow release from tissues.
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Gadolinium: pharmacokinetics and toxicity in humans and laboratory ...
The elimination half-life of gadodiamide in patients with severe renal disease (glomerular filtration rate [GFR] of 2–10 mL/min) is 34.3 h ± 22.9, compared with 1.3 h ± 0.25 in those with no renal dysfunction, as a result of reduced clearance by poorly functioning kidneys (Joffe et al. 1998).
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Pharmacology, Part 5: CT and MRI Contrast Media
Given the long biologic half-life of free gadolinium and the long retention of lanthanides in bone, it is important to consider the lifelong burden of gadolinium, especially in those have multiple contrast studies over their life-span .
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Detection and imaging of gadolinium accumulation in human bone tissue ...
Though the blood elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some tissues retain gadolinium, which might further pose a health threat due to...
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Biodistribution of gadolinium-based contrast agents, including ...
Clearance of gadolinium from the liver and spleen showed a half-life of 3 to 4 days. In the case of Gd-DTPA loaded liposomes there is an efficient uptake by the reticuloendothelial systems (RES) as occurs for any kind of i.v. administered particles.
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What nephrologists need to know about gadolinium - Nature
In people with a normal GFR, the half-life of gadolinium was 1.96 hours. It increased to 6.11 ± 2.95 hours in those with a GFR of 31–60 ml/min per 1.73 m 2 and to 9.48 ± 3.08 hours in those...
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